https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49804 Wed 31 May 2023 15:59:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1472 Wed 11 Apr 2018 15:28:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10848 Wed 11 Apr 2018 15:16:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22360 Wed 11 Apr 2018 13:15:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8690 Wed 11 Apr 2018 13:04:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2938 Wed 11 Apr 2018 10:58:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24691 Phyllanthus amarus is known as a healing herb which has traditionally been used in the treatment of various diseases such as hepatitis, diabetes and cancer. The extraction parameters have great effects on the extraction efficiency of bioactive compounds and pharmacological activity of the extracts. This study sought to optimise the microwave-assisted extraction parameters for phenolic compounds-enriched extracts and antioxidant capacity from P. amarus using response surface methodology (RSM). The results showed that the optimal microwave-assisted extraction parameters were an extraction time of 30 min, an irradiation time of 14 s min⁻¹ and a ratio of solvent to sample of 150 mL g⁻¹. The total phenolic content, phenolic extraction efficiency, saponin content, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging capacity, 2,2-diphenyl-1-picryl-hydrazil (DPPH) radical scavenging capacity and ferric reducing antioxidant power of the P. amarus achieved under these optimal parameters were 87.3 mg of gallic acid equivalents (GAE) per gram of dried sample, 69.7 %, 134.9 mg of escin equivalents (EE) per gram of dried sample, 997.8, 604.7 and 437.3 all in mg of trolox equivalents (TE) per gram of dried sample, respectively, which were not significantly different from the predicted values (86.9 mg of GAE per gram of dried sample, 67.3 %, 123.5 mg of EE per gram of dried sample, 1013.3 mg of TE per gram of dried sample, 530.6 mg of TE per gram of dried sample and 423.5 mg of TE per gram of dried sample, respectively). Accordingly, the optimal microwave-assisted extraction parameters of 30 min, 14 s min⁻¹ and 150 mL g⁻¹ are recommended for the extraction of enriched phenolics from P. amarus for potential application in the nutraceutical and pharmaceutical industries.]]> Wed 09 Feb 2022 15:54:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32209 Wed 04 Sep 2019 12:18:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29924 Wed 04 Sep 2019 12:16:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33080 −1, respectively. The carotenoid extraction yield and the antioxidant capacity extraction yield were 271 mg/100 g DW and 737 μm TE/100 g DW, respectively. Thus, the extraction using ethyl acetate with the ratio of 80:1 (mL solvent per g Gac peel) for 150 min at 40.7°C is suggested for recovering carotenoids and antioxidant capacity from Gac peel.]]> Wed 04 Sep 2019 09:54:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39872 a deliberate, iterative and data-driven process to improve a health intervention and/or its implementation to meet stakeholder-defined public health impacts within resource constraints. This study aimed to identify frameworks used to optimise the impact of health interventions and/or their implementation, and characterise the key concepts, steps or processes of identified frameworks. Methods: A scoping review of MEDLINE, CINAL, PsycINFO, and ProQuest Nursing & Allied Health Source databases was undertaken. Two reviewers independently coded the key concepts, steps or processes involved in each frameworks, and identified if it was a framework aimed to optimise interventions or their implementation. Two review authors then identified the common steps across included frameworks. Results: Twenty optimisation frameworks were identified. Eight frameworks were for optimising interventions, 11 for optimising implementation and one covered both intervention and implementation optimisation. The mean number of steps within the frameworks was six (range 3–9). Almost half (n = 8) could be classified as both linear and cyclic frameworks, indicating that some steps may occur multiple times in a single framework. Two meta- frameworks are proposed, one for intervention optimisation and one for implementation strategy optimisation. Steps for intervention optimisation are: Problem identification; Preparation; Theoretical/Literature base; Pilot/ Feasibility testing; Optimisation; Evaluation; and Long-term implementation. Steps for implementation strategy optimisation are: Problem identification; Collaborate; Plan/design; Pilot; Do/change; Study/evaluate/check; Act; Sustain/endure; and Disseminate/extend. Conclusions: This review provides a useful summary of the common steps followed to optimise a public health intervention or its implementation according to established frameworks. Further opportunities to study and/or validate such frameworks and their impact on improving outcomes exist.]]> Tue 28 Jun 2022 14:33:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36178 Tue 25 Feb 2020 09:45:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51130 Tue 22 Aug 2023 15:51:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37486 Tue 19 Jan 2021 18:35:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44623 Tue 18 Oct 2022 10:29:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34559 Tue 03 Sep 2019 18:30:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37278 Salacia chinensis L. root; investigate the impact of solvents on yield; optimise the ultrasound-assisted extraction (UAE) technique; and compare mangiferin yield with continuously shaking extraction (CSE) and decoction techniques. The results showed that mangiferin, with a purity of over 88%, could be achieved by HPLC using a mixture of solvent A (water: acetonitrile: orthophosphoric acid, 96.8:3:0.2 (v/v/v)) and solvent B (acetonitrile). Solvent type significantly affected the extraction yield of mangiferin, and a mixture of acetone and water gave the highest extraction yield, as compared to other solvents or mixtures. UAE conditions, such as ultrasonic power, temperature, time and concentration of acetone significantly affected the extraction of mangiferin. Optimal UAE conditions were at an ultrasonic power of 250 W, temperature of 50 °C, acetone concentration of 40% and extraction time of 60 min. These optimal conditions could extract approximately 92 mg, whereas CSE and decoction only extracted 89.20 mg and 58.71 mg of mangiferin, respectively, from 1 g of S. chinensis root. Therefore, these UAE conditions are recommended for the extraction of mangiferin from S. chinensis root for further utilisation.]]> Thu 27 Jan 2022 15:56:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39154 Momordica cochinchinensis) is a tropical fruit. It belongs to the Cucurbitaceae family. Gac pulp (or mesocarp) that accounts for 40-50% of fruit weight is commonly discarded during the processing of Gac fruit. However, this by-product is a rich source of nutrients and bioactive compounds, which are potential to produce edible films. This study aimed to determine the effect of sodium alginate, kappa-carrageenan, Gac pulp and glycerol on film properties and optimise the formula of this composite film for further applications using a response surface methodology (RSM). The results showed that sodium alginate, kappa-carrageenan, Gac pulp, and glycerol affected physical and barrier properties, colour parameters, and mechanical properties of the films. The optimal formulation to generate a composite film from Gac pulp include sodium alginate 1.03%, kappa-carrageenan 0.65%, Gac pulp 0.4%, and glycerol 0.85% (w/v), where this film produces high mechanical properties, low water vapour permeability and acceptable physical properties. This optimised film formulation demonstrates a potential for food application.]]> Thu 19 May 2022 16:15:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37414 Thu 12 Nov 2020 17:17:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42695 Thu 01 Sep 2022 09:34:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8741 Sat 24 Mar 2018 10:44:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8875 Sat 24 Mar 2018 08:40:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8956 Sat 24 Mar 2018 08:37:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9531 Sat 24 Mar 2018 08:35:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18873 Sat 24 Mar 2018 08:03:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19952 Sat 24 Mar 2018 07:58:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20293 Sat 24 Mar 2018 07:55:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28484 Davidsonia pruriens F. Muell) and to assess the physicochemical and antioxidant properties of the phenolic-enriched extract. The results showed that temperature, time and ratio significantly affected the extraction of TPC. Optimization of extraction conditions was performed using response surface methodology (RSM) utilising a Box–Behnken design. Optimal extraction conditions were determined to be temperature: 90 °C, extraction time: 30 min and solvent to mass ratio: 20:1 mL g⁻¹. The extracted solid obtained under these conditions had low-moisture content, high water solubility and contained 45 mg GAE g−1 of TPC, 22 mg RUE g⁻¹ of flavonoids, 3.2 mg CAE g⁻¹ of proanthocyanidins, 2 mg CGE g⁻¹ of anthocyanidins and 56 mg ACE g⁻¹ vitamin C. The extract possessed potent antioxidant capacity, but was comparatively lower than those of vitamin E and BHT. Thus, Davidson's plum should be further investigated for its potential health promoting benefits and utilisation in the nutraceutical and food industries.]]> Sat 24 Mar 2018 07:39:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28009 Eucalyptus robusta (E. robusta) has a significant value in traditional medicine and recently has been shown to possess many pharmacological properties in vitro. This study was designed to utilise microwave-assisted extraction (MAE) to yield optimal total phenolic content (TPC), total flavonoid content (TFC), proanthocyanidin levels and antioxidant capacity from E. robusta using water as the solvent, facilitated by the use of response surface methodology (RSM). A three-level-three-factor Box–Behnken design was implemented to elucidate the effect of irradiation time, power and sample-to-solvent ratio on the yields of these phytochemicals. The results highlighted the accuracy and reliability of RSM as a tool for predicting the yields of TPC, TFC, proanthocyanidins and total antioxidants using MAE. Sample-to-solvent ratio had the greatest impact on the TPC yield followed by power and irradiation time. The optimal MAE conditions for TPC and TFC were 3 min, 600 W power and 2 g/100 mL sample-to-solvent ratio. The experimental yield of TPC was 58.40 ± 1.03 mg GAE/g, and 19.15 ± 1.06 mg RE/g of TFC was obtained under these optimal conditions. These conditions, optimised for maximum TPC yield also liberated 62%, 64.6%, 66.3% and 67% of the maximum proanthocyanidins, ABTS, DPPH and CUPRAC values, respectively. This study revealed that MAE is a reliable and efficient method for extracting high yields of phytochemicals from E. robusta, with significant potential to be up-scaled for industrial, nutraceutical or pharmaceutical applications.]]> Sat 24 Mar 2018 07:27:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25888 Sat 24 Mar 2018 07:25:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3345 Sat 24 Mar 2018 07:18:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23686 Sat 24 Mar 2018 07:13:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24994 Sat 24 Mar 2018 07:09:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46639 Mon 28 Nov 2022 16:19:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32365 Mon 28 May 2018 13:32:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33228 Mon 23 Sep 2019 12:58:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33548 Mon 23 Sep 2019 11:19:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16202 Mon 20 Nov 2023 14:40:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44563 Mon 17 Oct 2022 11:09:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45814 Mon 07 Nov 2022 11:50:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36529 Fri 29 May 2020 13:47:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15855 Fri 24 May 2019 11:49:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33068 Hormosira banksii for total phenolic content (TPC) and antioxidant activities including total antioxidant capacity (ABTS), DPPH free radical scavenging capacity (DPPH) and ferric reducing antioxidant power (FRAP) using response surface methodology (RSM). Box–Behnken design was employed to assess the effect of ultrasonic temperature, time and power on the TPC and antioxidant activities of the extracts. The results showed that RSM was an accurate and reliable method in predicting TPC and antioxidant activities (ABTS, DPPH and FRAP) of the extracts with R² values of 0.97, 0.96, 0.92 and 0.94, respectively. The ultrasonic temperature and time had the significant impact on TPC and antioxidant capacities. The optimal UAE conditions for the maximal values of TPC and antioxidant activities were of 30 °C, 60 min and power 60%, or 150 W. The values of TPC and antioxidant activities (ABTS, DPPH, FRAP) achieved under these parameters were 23.12 (mg GAE g⁻¹), 85.64 (mg TE g⁻¹), 47.24 (mg TE g⁻¹) and 12.56 (mg TE g⁻¹), respectively. UAE was found to be more efficient in comparison to conventional extraction, with shorter time for extraction and higher of TPC level and antioxidant activities. Therefore, ultrasonic-assisted extraction using RSM is effective for extraction and further isolation and purification of phenolic compounds from H. banksii. In addition, this alga could be a potential rich source of natural antioxidants applied in food and pharmaceutical fields.]]> Fri 24 Aug 2018 13:44:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33066 Fri 24 Aug 2018 13:44:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33846 Fri 18 Jan 2019 14:48:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46763 Fri 16 Feb 2024 11:21:01 AEDT ]]>